Hm I guess for me it would depend on if I'm defending as my kintype or my profile pic. If I'm my kintype, then I'll be fine haha immortality and such. If I'm defending as my profile pic, could go either way given it's a pretty venomous snake versus a coyote.
In my human body though? If the coyote is persistent enough, I don't think I'd stand a chance The best defense strategy I know is to shout, "WHAT'S THAT OVER THERE?" then run in the opposite direction when they look at it.
Add crazy acrobatic skills and overpowered weapons to that list above. (Although there are better frames than Inaros for singular boss fights. It would be easier if you brought a dozen of your weaker friends so he can steal their health.)